toxoplasmosis cerebri
Advices
| Priority | Medication | Remarks |
|---|---|---|
|
Priority: 1st choice |
Medication: sulfadiazine po 1500mg 4dd 6 weeks +
pyrimethamine po loading dose 200mg, 75mg 1dd 6 weeks +
folinezuur po 15mg 1dd 6 weeks |
|
|
Priority: 1st choice alternative |
Medication: cotrimoxazol (trimethoprim +sulfamethoxazol) iv or po 5/25mg/kg 2dd 6 weeks |
|
|
Priority: 2nd choice |
Medication: clindamycine iv 600mg 4dd 6 weeks +
pyrimethamine po loading dose 200mg, 75mg 1dd 6 weeks +
folinezuur po 15mg 1dd 6 weeks |
Remarks:
SWAB remarks clindamycine iv of po |
|
Priority: 3rd choice |
Medication: atovaquon po 1500mg 2dd 6 weeks +
pyrimethamine po loading dose 200mg, 75mg 1dd 6 weeks +
folinezuur po 15mg 1dd 6 weeks |
Remarks:
SWAB remarks suspensie, innemen met voedsel |
Sources
-
https://richtlijnhiv.nvhb.nl/index.php/Profylaxe_en_behandeling_van_opportunistische_infecties
Richtlijnen Ned. Ver. van HIV behandelaars
-
NVP therapierichtlijn 2020_30.pdf
Therapierichtlijn Parasitaire infecties 2020, Nederlandse Vereniging voor Parasitologie
-
clinicalinfo.hiv.gov
DHHS Guidelines (NIH)
Antimicrobial resources
The following antimicrobial agents have been used in these recommendations:
External antimicrobial resources
Menu position
Metadata
Swab vid: G-8313.5
Updated: 05/20/2025 - 13:52
Status: Published
General comments
NB! Gewicht < 60 kg: dosering sulfadiazine po 1000 mg 4dd, dosering pyrimethamine po 50 mg 1 dd (oplaaddosis 200 mg)
Behandelduur 6 weken. Na behandeling secundaire profylaxe.
Primaire profylaxe indien CD4+cellen <100cellen/µl; cotrimoxazol po 480mg 1dd blijkt in de praktijk effectief.
Ernstige symptomatische toxoplasmose bij immuuncompetente gastheer: bovenstaand regime gedurende 2—4 weken.
Na behandeling secundaire profylaxe.