Harvoni
      J - Antiinfectives For Systemic Use -> J05 - Antivirals For Systemic Use -> J05A - Direct Acting Antivirals -> J05AX - Other Antivirals -> J05AX65 - Harvoni
    
          
        Administration category:
         Free
      
    
          
        Medicine group:
        antiviral
      
    
          
        File parts:
                  ledipasvir
                  sofosbuvir
              
    
          
        Brand name:
                  Harvoni
              
      Standard dosages
| Weight | ROA | Load | Dosage | |
|---|---|---|---|---|
| ROA: po | Load: - | Dosage: 90/400mg 1 dd | ||
| Comments: = 1 tablet per dag | ||||
Kidney function
| ROA | GFR | Dosage | Interval | Comments | 
|---|---|---|---|---|
| ROA: po | ||||
| GFR: <30 | Dosage: veiligheid en effectiviteit niet bewezen | |||
              
                Renal elimination: 
                ledipasvir: 1%    sofosbuvir: 80%
              
            
                    
                                
              
                Dosage: 
                dependent on kidney function
              
            
                    
        Pregnancy
Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:
- http://www.lareb.nl//Teratologie/Naslagwerk-GZB/GZB---Zwangerschap#TOC_Middelen_bij6
- http://www.lareb.nl//Teratologie/Naslagwerk-GZB/GZB---Borstvoeding#TOC_Middelen_bij16
          
            For individual advice, consult an expert on site.          
        
      Metadata
            Swab vid: M-343591.1
            Updated: 06/16/2019 - 20:05
            Status: Published
          
